Primal N2O™—Pre-workout Performance, Nitric Oxide, and Energy Booster

Primal N2O, The Final Pre-Workout Solutionâ„¢, features scientifically-proven ingredients that support increased performance, promote skin-stretching muscle pumps, and support lean mass gains. Primal N2O contains synergistic ingredients that work together to take your training and results to the next level and beyond. This scientifically advanced formula has been clinically shown to:

• Support increased performance and lean mass gains.*
• Support increased blood flow and amino acid delivery to skeletal muscle, leading to increased protein synthesis
  (muscle growth).*
• Support increased energy and mental focus while delaying fatigue, allowing you to workout harder and longer.*
• Speed recovery.*
• Enhance ATP production and support cell volumization.*
• Support optimal growth hormone levels.*

We recommend taking Primal N2O 30-45 minutes pre-training. For optimal results, consume Scivation Xtendâ„¢ during training.

            We have formulated Primal N20 around ingredients that are scientifically proven to increase performance and muscle growth. Primal N20 contains synergistic ingredients that work together to take the results you will see to the next level and beyond.

1. Creatine + Citrulline Malate

• Synergistically increases performance

2. Creatine + Beta-Alanine

• Synergistically increases performance and lean mass gains

3. Citrulline Malate + Arginine

• Increases blood flow and amino acid deliver to skeletal muscle, leading to increased protein synthesis (muscle growth)

4. Tyrosine + ALCAR + Caffeine

• Increases energy and mental focus while delaying fatigue, allowing you to workout harder and longer.

Let’s take a more indepth look at Primal N20's ingredients.

N20 Drive â„¢ Blend
(Creatine Monohydrate, Di Creatine Malate)

Creatine is used in the high-energy phosphate or ATP-PCr system to regenerate ATP. ATP, the body's main source of energy, is a molecule of adenosine (adenine + the sugar ribose) linked to three phosphate molecules by high-energy bonds. Breaking of the two outer bonds results in the release of energy.
When the most outer bond is broken, the energy is released and ADP and Pi are left behind. Creatine, which is bonded to a phosphate ion, transfers energy to the ADP and Pi molecule by breaking its own bond. This regenerates the ATP molecule, which means one now has more energy to use. Skeletal muscle has a limited storage of creatine. Therefore supplementing with creatine increases your ability to form ATP and therefore increases the available energy for exercise (Casey et al. 1996 & 2000). Creatine has been shown to:

• Increase muscle size and strength (Willoughby, 2001)
• Increase power output (Becque, 2000)
• Increase high-intensity exercise performance (Tarnopolsky, 2000)
• Increase work capacity (Rico-Sanz, 2000)

Creatine is one of the most scientifically proven-effective supplements on the market, with creatine monohydrate being the form used in most studies.

CreaPrimeâ„¢ Blend
Citrulline Malate , L-Arginine Alpha KetoGlutarate 2:1, (Di-L-Arginine)-L-Malate, Citric Acid, (Di-L-Arginine) Orotate
           
The rate-limiting step of amino acid uptake into skeletal muscle is the transportation of the amino acids through the blood to the skeletal muscle, which is governed by blood flow (Wolfe, 2004). NO vasodilates blood vessels, thereby increasing blood flow. This increase when combined with exercises means greater blood flow and greater amino acid deliver and uptake in the working skeletal muscle. Exercise itself results in an increase in NO production, and the increased blood flow created by exercise is believed to be linked to the increase in protein synthesis post workout (Douglas et al., 2004). Di-Arginine Orotate, AAKG, Di-Arginine Malate, and Citrulline Malate all increase NO production and blood flow to skeletal muscle.
Citrulline-Malate has been shown to increase the rate of oxidative ATP production during exercise and the rate of phosphocreatine replenishment post exercise (Bendahan, 2002). Increasing the rate of ATP production during exercise would increase performance and energy.
            Citrulline-Malate also has anti-fatigue properties due to its ability to decrease ammonia levels and prevent against metabolic acidosis (Callis, 1991). Decreasing the sensation of fatigue would allow one to workout harder and longer, and thereby burn more calories and lose more fat.
            Both Citric Acid and Malic Acid (Malate) are intermediates in the Kreb’s cycle, which produces ATP. Adding citric acid and malic acid to N20 aids in ATP production.

H-Primer Blend
(Beta-Alanine, NAC)

Beta-Alanine

It has been shown that skeletal muscle carnosine levels are correlated with performance during high-intensity exercise (Suzuki, 2002). Carnosine is an important metabolic buffer in skeletal muscle (Suzuki, 2002), which means it helps maintain the acid-base balance in the presence of high H+ concentrations. High levels of H+ during exercise cause fatigue and decrease performance.
Beta-alanine is one of the two amino acids (histidine being the other) that makes up the dipeptide carnosine (L-beta-alanyl-L-histidine). Growing research shows Beta-alanine to be a very effective performance enhancers and lean mass building supplement. Research shows:

• Beta-Alanine availability is the limiting factor in muscle carnosine synthesis (Hill, 2007).
• Muscle carnosine levels were higher after 10 weeks of beta-alanine supplementation than after 4 weeks, showing that beta-alanine’s effects are best experienced over long term supplementation (Hill, 2007).
• Beta-alanine supplementation increases total work done during aerobic exercise (Hill, 2007).
• Beta-alanine enhances endurance performance (Zoeller, 2006)
• Beta-Alanine delays the onset of neuromuscular fatigue (Stout, 2006)
• Adding beta-alanine to creatine supplementation leads to greater increases in lean mass than creatine alone (Hoffman, 2006).

It is clear that current research shows Beta-Alanine to be an effective performance enhancer and enhances lean mass gains when combined with creatine.

NAC

N-acetyl-cysteine (NAC) is derived from the non-essential amino acid cysteine. Because cysteine is very unstable, supplementing with NAC allows one to get the benefits of cysteine. NAC is an antioxidant itself (Aruoma, 1989) and is also used to synthesize the antioxidant glutathoine. Glutathione is a powerful antioxidant and also regenerates vitamin C and E (Bounous, 1999)
Since intense exercise depletes glutathione (Sen, 1999), supplementation of NAC can is beneficial to increase glutathione levels. Oxidative stress caused by free radicals (H+), causes fatigue and muscular soreness. Supplementing with NAC will enhance athletic performance by scavenging these free radicals (Lands, 1999).

BrainDrive Blend
(N-Acetyl Tyrosine, ALCAR, Caffeine)

N-Acetyl-L-Tyrosine

Tyrosine is a nonessential amino acids used to make the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine, thyroid hormones, and the skin pigment melanin. Stress, such as exercise, depletes the amount of dopamine and norepinephrine in the brain. Tyrosine supplementation has been shown

• Decrease the negative effects of stress (Banderet, 1989)
• Decrease fatigue and increase cognitive performance (Neri, 1995)
• Decrease cardiovascular stress and enhance cognitive activity (Dollins, 1995)

ALCAR

The amino acid L-Carnitine plays a vital role in energy metabolism, specifically the transport of fatty acids into mitochondria where they can be oxidized. ALCAR is the acetylated form of carnitine and is the most popular form of supplemental carnitine. ALCAR is a potent antioxidant shown to have anti-aging, cardio-protective, cognitive enhancing, and adaptogen properties.  ALCAR increases exercise performance by

• Increasing fat oxidation (Hongu, 2003)
• Decreasing muscle soreness (Giamberardino, 1996)
• Decreasing lactic acid accumulation (Siliprandi, 1990).

Caffeine

Caffeine, a plant alkaloid belonging to the drug class methylxanthines and is found in natural sources such as coffee beans, tea leaves, cocoa beans, and other plants, is the world’s most widely used stimulant.  Caffeine is a Central Nervous System (CNS) stimulant shown to delay fatigue and improve cognitive performance.
Caffeine acts as an adenosine receptor antagonist. Adenosine decreases the release of stimulatory/excitatory neurotransmitters (i.e. norepinephrine [NE]). Therefore, blocking the adenosine receptor allows a greater excitation to occur by increasing NE’s ability to activate the adrenergic receptors.
Caffeine inhibits phosphodiesterase (PDE), causing a build-up of cAMP levels and greater effect of NE on fatty acid lipolysis. PDE blunts lipolysis; therefore inhibiting PDE allows lipolysis to proceed at an accelerated rate. The end result is there are more fatty acids available for oxidation after consumption of caffeine, which is one of the ways caffeine is believes to increase performance.

D,L-Phenylalanine

D,L-Phenylalanine is a 50/50 mix of D-Phenylalanine and L-Phenylalanine. L-Phenylalanine is an essential amino acid while D-Phenylalanine is a non-protein amino acid that is not used in protein synthesis. Phenylalanine can be metabolized to PEA and is also a precursor for norepinephrine and dopamine.

B-Vitamins
(50mg B6, 50mg B5, 100 mcg B12, 75mg Niacin)    

The B vitamins are essential to whole body energy metabolism, We included the B vitamins in N20 to ensure your body has what it needs to perform at its full potential.

Wrap-Up

            Primal N20 is formulated to allow you to increase the intensity of your workouts while delaying fatigue, which results in greater progress being made. Primal N20 increases energy production and power output, decreases H+ accumulation and fatigue, and increases blood flow and the deliver of amino acids to skeletal muscle, making it an all-in-one pre-workout powerhouse. We highly recommend combining 1 serving of Primal N20 with 1 serving of Primal EAA 15-20 minutes pre-workout to give your body EVERYTHING it needs to perform and progress like never before.